dimanche 28 décembre 2014

How Vaccine Formulation Development Assists In Infection Elimination

By Stacey Burt


As medical science progresses and medicines and surgical techniques become progressively more sophisticated, their impact on the patient and society at large becomes less predictable and, at the same time, more impressive, where they are successful. In turning to modern medicine for solutions to their health problems, people are usually satisfied with the response that they receive. However, there remain certain illnesses which cannot be cured, and these are typically caused by pathogens known as viruses. Vaccine formulation development is an essential process in trying to counter viruses and their spread.

The standard response nowadays to infection is to resort to an antibiotic. However, viruses do not respond to these, because they are not biotic organisms. Technically, they are not alive, so antibiotic measures are useless in trying to eliminate them. Surgery and other procedures, such as radiation, are equally non-applicable. The only sure measure is a vaccine.

It operates on the basis of a very simple principle. It mimics infection by the targeted virus in the patient's body, and thereby encourages the body to develop viral anti-bodies. The body produces the anti-bodies as soon as it detects the vaccine.

These antibodies are only manufactured by the human immune system. They entirely eliminate the viral particles. Once the infection has been destroyed, though, the antibodies remain in the system indefinitely, preventing any future recurrence of that specific virus. By using immunization, life-long immunity is therefore generated without authentic infection taking place.

The process of the immunization of infants and young kids is based on this principle. They are typically immunized against common yet serious diseases like measles and polio. Immunization has become a standard practice, yet it is necessary. Smallpox and polio, two supposedly archaic names, used to be substantial threats to public health and maimed, disfigured or killed many people.

Some of the most lethal or serious sicknesses are the result of viral activity. The hemorrhagic fever Ebola is one, as is AIDS, meningitis (in one of its forms), and, as mentioned in the preceding paragraph, polio (which paralyses the patient if left untreated). Targeting these viruses for immunization development is obviously a primary priority in modern medicine. The public recognizes this priority, and the media are not slow to report on attempts to formulate an antidote to a notorious disease, no matter how empty such attempts may turn out to be.

A virus may re-surface in a medication-resistant form in time. This happens if it is able to mutate into an unknown form, or one against which the antibodies in the patient are not effective. This may sound extreme or unlikely, but it happens every year with the influenza virus, which is why there is no viable vaccine for flu, or for the common cold, either. These viruses simply mutate too quickly and cannot be permanently countered.

As effective as a vaccine may be, the public should also be aware that sensible personal health habits are important too. Observing simple principles of personal safety and health are important in limiting or preventing infections and epidemics, especially where the disease is incurable, such as AIDS. In such cases, there is no vaccine, and so relying on one is neither an option nor is it necessary.




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